@article{Aydoğan_Bahçecioğlu Mutlu_Keskin_Özalp Ateş_Güllü_2019, title={The Impact of Serum C-peptide Level on Bone Mineral Density in Postmenopausal Type 2 Diabetic Women.: Bone mineral density and serum c-peptide.}, volume={6}, url={https://medscidiscovery.com/index.php/msd/article/view/274}, DOI={10.36472/msd.v6i9.274}, abstractNote={<p><strong>Objective: </strong>Recent studies suggested that c-peptide had biological activity on bone metabolism. We aimed to evaluate the impact of c-peptide level on bone mineral density (BMD) in postmenopausal type 2 diabetic women.</p> <p><strong>Methods: </strong>Thirty-five insulin naïve type 2 diabetic postmenopausal women were included in our prospective cohort study. Fasting and random c-peptide, parathyroid hormone (PTH), vitamin D, insulin, alkaline phosphatase level (ALP) levels and BMD were evaluated.</p> <p><strong>Results: </strong>The mean age of patients was 61.8±8.56 years. The mean fasting c-peptide, random c-peptide and insulin levels were 3.0±1.24, 7.7±3.7 and 13.9±11.2 µIU/ml, respectively. The mean femoral neck (FN-BMD) and total lumbar spine bone mineral density (L-BMD) were 0.787±0.127 and 0.919±0.122 g/cm<sup>2</sup>, respectively. C-peptide level was associated with total hip BMD (p<0.05) but this relation disappeared after regression analysis adjusted for confounders. A negative correlation between PTH level and FN-BMD was found (p=0.01). Total hip BMD and L-BMD were negatively correlated with age (p=0.01 and p=0.02, respectively). A positive association between DPP4 inhibitor treatment and total hip BMD was observed (p=0.03).</p> <p><strong>Conclusions: </strong>We observed a positive association between total hip BMD and serum c-peptide level. However, this relationship disappeared in multiple linear regression analysis. Further studies are necessary to evaluate the impact of c-peptide level on the risk of osteoporosis in T2DM.</p>}, number={9}, journal={Medical Science and Discovery}, author={Aydoğan, Berna İmge and Bahçecioğlu Mutlu, Adile Begüm and Keskin, Çağlar and Özalp Ateş, Funda Seher and Güllü, Sevim}, year={2019}, month={Sep.}, pages={166–172} }