Prevalence of Helicobacter pylori infection in patients with Dementia who underwent Percutaneous Endoscopic Gastrostomy (PEG) and the effect of preventive single dose ceftrixone plus pantaprazole therapy on Helicobacter pylori infection
Article Sidebar
Main Article Content
Abstract
Objective: This was a retrospective study of the hospital database from April 2020 to January 2021 to reveal the rate of Helicobacter pylori infection among Dementia patients who underwent percutaneous endoscopic gastrostomy (PEG) procedure. Other aim of this study is examine the effect of a single dose (two grams) intravenous ceftriaxone plus pantoprazole (40 mg) before PEG procedure on H.pylori infection in Dementia patients.
Material and Methods: This is a retrospective observational study of hospital database from April 2020 to January 2021 examining the effect of using a single dose (two grams) of intravenous ceftriaxone plus pantoprazole (40 mg) on H.pylori infection in Dementia patients. A total of 77 patients, (43 (64%) of them were female) with Dementia were included whose 67 had previously been diagnosed as Dementia and underwent PEG procedure. The control group (67 subjects; 40 of them were female and the mean age was 75.8±11 years) was selected from age and gender-matched dyspeptic subjects who underwent endoscopy
Results: While the mean age in the Dementia group was 75.8±12 years, the mean age of the control group was 77.8 ±11 years (p=0.054). There were also no gender differences between groups (p=0.594).
While the mean levels of serum albumin, urea, creatinine, hemoglobin were significantly lower than control subjects (All p values were below 0.001), the mean of serum ferritin level was higher than control subjects (p<0.01). The presence of H.pylori on gastric biopsy specimens was significantly lower in the Dementia group compared to control subjects (19.4% versus 55.2%).
Conclusion: Our study indicated that the rate of H.pylori infection was lower than estimated and using single-dose intravenous ceftriaxone at a dose of 2 grams could be beneficial for treating H.pylori infection in patients with Dementia who faced difficulties related to lack of swallowing many drugs against H.pylori infection.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Accepted 2022-02-24
Published 2022-03-01
References
Agostini S, Clerici M, Mancuso R. How plausible is a link between HSV-1 infection and Alzheimer’s disease? Expert Review of Anti-infective Therapy. 2014; 12(3): 275-278. DOI: https://doi.org/10.1586/14787210.2014.887442
Mawanda F, Wallace R. Can Infections Cause Alzheimer’s Disease? Epidemiologic Reviews. 2013; 35: 161-180. DOI: https://doi.org/10.1093/epirev/mxs007
Elke G, Zanten ARH, Lemieux M, et al. Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials. Crit Care. 2016;20(1):117. DOI: https://doi.org/10.1186/s13054-016-1298-1
Segal R, Dan M, Pogoreliuk I, Leibovitz A. Pathogenic colonization of the stomach in enterally fed elderly patients: Comparing percutaneous endoscopic gastrostomy with nasogastric tube. Journal of the American Geriatrics Society. 2006; 54: 1905-8. DOI: https://doi.org/10.1111/j.1532-5415.2006.00964.x
Rey JR, Axon A, Budzynska A, et al. Guidelines of the European Society of Gastrointestinal Endoscopy (E.S.G.E.) antibiotic prophylaxis for gastrointestinal endoscopy. European Society of Gastrointestinal Endoscopy. Endoscopy 1998;30:318-24.
Kochar T, Abugroun A, Nayyar A, Abdel-Rahman M, Patel PJ. Racial and Socioeconomic Disparities in Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement among elderly patients with Dementia in the United States from the National inpatient sample. 2020. doi:10.21203/rs.3.rs-28267/v1 DOI: https://doi.org/10.21203/rs.3.rs-28267/v1
Volkert D, Chourdakis M, Faxen-Irving G, et al. ESPEN guidelines on nutrition in Dementia. Clin Nutr. 2015;34(6):1052-1073. doi:10.1016/J.CLNU.2015.09.004 DOI: https://doi.org/10.1016/j.clnu.2015.09.004
Jonkers-Schuitema CF, Camilo ME. Basics in clinical nutrition. In: Sobotka L, ed. Basics in Clinical Nutrition. Prague 5: Publishing House Galén; 2019:531-536. https://www.espen.org/education/espen-blue-book. Accessed January 6, 2022.
Panebianco M, Marchese-Ragona R, Masiero S, Restivo DA. Dysphagia in neurological diseases: a literature review. Neurol Sci. 2020;41(11):3067-3073. doi:10.1007/s10072-020-04495-2 DOI: https://doi.org/10.1007/s10072-020-04495-2
Kountouras J, Boziki M, Gavalas E, Zavos C, Deretzi G, Chatzigeorgiou S, Katsinelos P, Grigoriadis N, Giartza-Taxidou E, Venizelos I. Five-year survival after Helicobacter pylori eradication in Alzheimer disease patients. Cogn Behav Neurol. 2010; 23(3): 199– 204. DOI: https://doi.org/10.1097/WNN.0b013e3181df3034
Roubaud-Baudron C, Varon C, Megraud F, Salles N. Alzheimer's disease and Helicobacter pylori infection: a possible link? Geriatr Psychol Neuropsychiatr Vieil. 2016; 14(1), 86- 94. DOI: https://doi.org/10.1684/pnv.2016.0584
Shao Y, Lu R, Yang Y, Xu Q, Wang B, Ye G. Antibiotic resistance of Helicobacter pylori to 16 antibiotics in clinical patients. J Clin Lab Anal. 2018 May;32(4):e22339. DOI: https://doi.org/10.1002/jcla.22339
DeLoney CR, Schiller NL. Competition of various beta-lactam antibiotics for the major penicillin-binding proteins of Helicobacter pylori: antibacterial activity and effects on bacterial morphology. Antimicrob Agents Chemother. 1999 Nov;43(11):2702-9 DOI: https://doi.org/10.1128/AAC.43.11.2702